Aloin ester.



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FARBENFABRIKEN' VOR'ML FRIEDR. GORPORATIUN QFGERMANY. i 4 ALQI N $89,974.. Specification of No Drawing.

earn

ESTER.

tettersl 'at n Patcnted Apr. id, thiii.

.Ap'plicaticn filed December 1%, 3,910. Serial No. acacia;

TdaZZ whom it may concerm'.

Be it known that we, WILHELM Hrnrrnnz and Enron Rnrrz, doctors of philosophy,

chemists, citizens of the German Empire, residing at Elberfeld, Germany, have invented new and'useful Improvements" in New Aloin Esters, of whichthe following is aspecificm' Aloin possesses as is known aluable-pur- "gative' or laxative properties. But its dis-- agreeable taste renders it objectionable for use. I

' We have now found that the hitherto 1111- .known mixed esters of aloin Withacetic acid and formic acid do not suffer from the above mentioned disadvantage. contain most probably 2 radicals of formic acid and- 3 radicals-of acetic acid, or'l radical of formic acid and 3 radicals of acetic acid. They areafter being dried and pub veri'zed' yellowish powders easily soluble in dilute caustic alkalis', glacial acetic acid,

"benzene, acetone, a'ndvhot alcohol. In con 'tradistinction to free ,aloin theygive no coloration with ferric chlorid; An average .dose as a laxative is about 0.1 gram. while about 0.2 gramis given as a purga-tive.

The processfor the production of the new compounds consists in treating aloin with a.

mixture of acetic acid anhydrid and formic acid or with the anhydrid of acetic acid 1 fully with formic acid.

- In-order to illustrate the new process more parts beingby we1ght Example 1-250 parts of aloin are heated to about 100. C. during 5; to J2- hours together with a mixture prepared from 210 The new -esters the following examples are given, the

parts: of acetic acid anhydrid, 90 parts of a 100 per cent. formic acid which mixture has chlorid of zinc. The ,limpid solution thus obtained is then introduced into- 5000 parts of ice water. The precipitate is filtered ea, washed, redissolved in hot alcohol and reprecipitated by introducing-the alcoholic solution into ice-water. It is filtered off again and dried. i

solved in 200 parts of acetic-formic'acid anhydrid of the formula:

crease 3 0 n 00 with formic acid and acetic acid, which are,

after being dried and pulverizedyellowish powders, soluble indilute caustic alkalis, glacial acetic acid, benzene and hot alcohol, giving no coloration with ferric chlorid;

as described.

,' In testimony whereof we have hereunto scribing witnesses.

WILHELM/HIEMENZ. [a 8. Enron nrnra. [L., s.]

Witnesses: I

- CHAS. J. WRIGHT, -WAL'1'ER Vonnren'r.

been heated to C. and 5 parts .ofmolten with the addition of 5 parts of zinc chlorid,

and being valuable purgatives, substantially set our hands in the presencebf two sub-' Enampiei 2: 50 parts of aloin, are dis- 

